Angewandte Chemie (International ed.), 2013-10, Vol.52 (41), p.10905-10908
International ed. in English, 2013
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Details
- Autor(en) / Beteiligte
- Titel
- Dynamic Nuclear Polarization NMR Spectroscopy: Revealing Multiple Conformations in Lipid-Anchored Peptide Vaccines
- Ist Teil von
- Angewandte Chemie (International ed.), 2013-10, Vol.52 (41), p.10905-10908
- Auflage
- International ed. in English
- Ort / Verlag
- Weinheim: WILEY-VCH Verlag
- Erscheinungsjahr
- 2013
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Sensitivity is the key: Dynamic nuclear polarization NMR spectroscopy provides structural information on liposomal vaccines targeting Alzheimer's disease. DMPC/DMPG/Cholesterol mainly stabilizes extended structures of the lipid‐anchored peptide, while in DMTAP/Cholesterol liposomes the peptide adopts a multitude of conformations including random‐coil and extended structures.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1433-7851eISSN: 1521-3773DOI: 10.1002/anie.201303374Titel-ID: cdi_proquest_miscellaneous_1701027047
- Format
- –
- Schlagworte
- Alzheimer Disease - prevention & control, Alzheimer's disease, Amino Acid Sequence, Amyloid beta-Peptides - administration & dosage, Amyloid beta-Peptides - chemistry, Cholesterol, dynamic nuclear polarization, Dynamics, Humans, Lipids - chemistry, liposomal vaccines, Liposomes, Liposomes - chemistry, Molecular Sequence Data, NMR spectroscopy, Nuclear Magnetic Resonance, Biomolecular, Peptide Fragments - administration & dosage, Peptide Fragments - chemistry, Peptides, Polarization, Vaccines, Vaccines, Subunit - administration & dosage, Vaccines, Subunit - chemistry, β-amyloid peptide