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Cascade Reactions: A Driving Force in Akuammiline Alkaloid Total Synthesis
Ist Teil von
Angewandte Chemie (International ed.), 2015-01, Vol.54 (2), p.400-412
Auflage
International ed. in English
Ort / Verlag
Weinheim: WILEY-VCH Verlag
Erscheinungsjahr
2015
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
The akuammiline alkaloids are a family of intricate natural products which have received considerable attention from scientists worldwide. Despite the fact that many members of this alkaloid class were discovered over 50 years ago, synthetic chemistry has been unable to address their architectures until recently. This minireview provides a brief overview of the rich history of the akuammiline alkaloids, including their isolation, structural features, biological activity, and proposed biosyntheses. Furthermore, several recently completed total syntheses are discussed in detail. These examples not only serve to highlight modern achievements in alkaloid total synthesis, but also demonstrate how the molecular scaffolds of the akuammilines have provided inspiration for the discovery and implementation of innovative cascade reactions for the rapid assembly of complex structures.
The akuammiline alkaloids are a family of terrestrial natural products which have a rich history and display promising therapeutic potential. Until recently, syntheses of these natural products have remained elusive. This Minireview describes several recently completed synthetic efforts, and illustrates how the akuammilines have provided inspiration for the discovery of novel cascade processes.