Details

Autor(en) / Beteiligte

• Nomura, Motoo
• Oze, Isao
• Abe, Tetsuya
• Komori, Azusa
• Narita, Yukiya
• Masuishi, Toshiki
• Taniguchi, Hiroya
• Kadowaki, Shigenori
• Ura, Takashi
• Andoh, Masashi
• Kawai, Ryosuke
• Uemura, Norihisa
• Ishihara, Makoto
• Tanaka, Tsutomu
• Tajika, Masahiro
• Niwa, Yasumasa
• Muro, Kei
• Muto, Manabu

Titel

Impact of docetaxel in addition to cisplatin and fluorouracil as neoadjuvant treatment for resectable stage III or T3 esophageal cancer: a propensity score-matched analysis

Ist Teil von

• Cancer chemotherapy and pharmacology, 2015-08, Vol.76 (2), p.357-363

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2015

Quelle

SpringerLink

Beschreibungen/Notizen

• Purpose To investigate the influence of addition of docetaxel to neoadjuvant chemotherapy (NAC) with cisplatin plus 5-fluorouracil (CF) in patients with clinical stage III or T3 esophageal squamous cell carcinoma. Methods Information about 209 esophageal cancer patients with stage III or T3 disease, who underwent NAC consisting of CF with or without docetaxel, was reviewed. The survival outcomes were analyzed using the Kaplan–Meier method and propensity score-adjusted Cox proportional hazards models. The relevant variables were included in the propensity score model. Results NAC was administered to 149 patients in the CF group and 60 patients in the docetaxel plus CF (DCF) group. Overall, 129 patients treated with CF and 58 patients treated with DCF underwent surgery after NAC. The overall response rate was significantly higher in the DCF group compared with the CF group (61.0 vs. 43.2 %, p  = 0.021). After matching, recurrence-free survival did not differ statistically between the CF and DCF groups [hazard ratio (HR) 0.83, 95 % confidence interval (CI) 0.50–1.37, p  = 0.46]. After matching, the improvement in overall survival in the DCF group reached statistical significance (HR 0.49, 95 % CI 0.24–0.999, p  = 0.050). No significant differences in rate of locoregional or distant recurrences were observed between the CF and DCF groups (53.0 vs. 48.3 %, p  = 0.54). Conclusions NAC with DCF is superior to CF in patients with clinical stage III or T3 esophageal squamous cell carcinoma.