Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
The Antipsychotic Olanzapine Interacts with the Gut Microbiome to Cause Weight Gain in Mouse: e115225
Ist Teil von
PloS one, 2014-12, Vol.9 (12)
Erscheinungsjahr
2014
Quelle
EZB Electronic Journals Library
Beschreibungen/Notizen
The second-generation antipsychotic olanzapine is effective in reducing psychotic symptoms but can cause extreme weight gain in human patients. We investigated the role of the gut microbiota in this adverse drug effect using a mouse model. First, we used germ-free C57BL/6J mice to demonstrate that gut bacteria are necessary and sufficient for weight gain caused by oral delivery of olanzapine. Second, we surveyed fecal microbiota before, during, and after treatment and found that olanzapine potentiated a shift towards an "obesogenic" bacterial profile. Finally, we demonstrated that olanzapine has antimicrobial activity in vitro against resident enteric bacterial strains. These results collectively provide strong evidence for a mechanism underlying olanzapine-induced weight gain in mouse and a hypothesis for clinical translation in human patients.
Sprache
Englisch
Identifikatoren
eISSN: 1932-6203
DOI: 10.1371/journal.pone.0115225
Titel-ID: cdi_proquest_miscellaneous_1694976300
Format
–
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von bX