Details

Autor(en) / Beteiligte

• Chen, Mei-Chin
• Ling, Ming-Hung
• Wang, Kuan-Wen
• Lin, Zhi-Wei
• Lai, Bo-Hung
• Chen, Dong-Hwang

Titel

Near-Infrared Light-Responsive Composite Microneedles for On-Demand Transdermal Drug Delivery

Ist Teil von

• Biomacromolecules, 2015-05, Vol.16 (5), p.1598-1607

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• This study presents near-infrared (NIR) light-responsive polymer–nanostructure composite microneedles used for on-demand transdermal drug delivery. Silica-coated lanthanum hexaboride (LaB6@SiO2) nanostructures were incorporated into polycaprolactone microneedles, serving as an NIR absorber. When the microneedles were irradiated with NIR light, light-to-heat transduction mediated by the LaB6@SiO2 nanostructures caused the microneedle melting at 50 °C. This increased the mobility of the polymer chains, enabling drug release from the matrix. Drug release from the microneedles was evaluated for four laser on/off cycles. In each cycle, the samples were irradiated until the temperature reached 50 °C for 3 min (laser on); the laser was then turned off for 30 min (laser off). The results showed that light-induced phase transition in the polymer triggered drug release from the melted microneedles. A stepwise drug-release behavior was observed after multiple cycles of NIR light exposure. No notable drug leakage was found in the off state. This NIR-light-triggerable device exhibits excellent reproducibility, low off-state leakage, and noninvasive triggerability and, thus, represents an advance in transdermal delivery technology.