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Fluorescent Gold Nanodots Based Sensor Array for Proteins Discrimination
Ist Teil von
Analytical chemistry (Washington), 2015-04, Vol.87 (8), p.4253-4259
Ort / Verlag
United States: American Chemical Society
Erscheinungsjahr
2015
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
A series of dual-ligand cofunctionalized fluorescent gold nanodots with similar fluorescence and diverse surface properties has been designed and synthesized to build a protein sensing array. Using this “chemical nose/tongue” strategy, fluorescence response patterns can be obtained on the array and identified via linear discriminant analysis (LDA). Eight proteins have been well distinguished at low concentration (A 280 = 0.005) based on this sensor array. The practicability of this sensor array was further validated by high accuracy (100%) examination of 48 unknown protein samples.