Details

Autor(en) / Beteiligte

• Walton, T. A.
• Nishtar, S.
• Lumb, P. J.
• Crook, M. A.
• Marber, M. S.
• Gill, J.
• Wierzbicki, A. S.

Titel

Pro-protein convertase subtilisin/kexin 9 concentrations correlate with coronary artery disease atheroma burden in a Pakistani cohort with chronic chest pain

Ist Teil von

• International journal of clinical practice (Esher), 2015-07, Vol.69 (7), p.738-742

Ort / Verlag

England: Blackwell Publishing Ltd

Erscheinungsjahr

2015

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Summary Objective To determine the relationship between proprotein convertase subtilisin kexin 9 (PCSK9) levels and atheroma burden in Pakistanis presenting to an ambulatory centre with chest pain. Methods A prospective matched case–control study of 400 patients selected for presence/absence of angiographic disease referred between 2001 and 2003. A comprehensive cardiovascular disease risk factor profile was assessed including demographics, environmental and biochemical risk factors including insulin resistance and PCSK‐9 levels. Coronary atheroma burden was quantified by Gensini score. Results In this population, PCSK‐9 levels were weakly correlated (r = 0.23) with male gender (p = 0.06) and number of diabetes years (p = 0.09), and inversely with log10 of lipoprotein (a) concentration (p = 0.07) but not LDL‐C. In multiple regression analysis, Gensini score was associated with age (p = 0.002), established angina (p = 0.001), duration of diabetes (p = 0.05), low HDL‐C (p < 0.001), lipoprotein (a) (p = 0.01), creatinine (p < 0.001), C‐Reactive Protein (p = 0.02) and PSCK‐9 (p = 0.05) concentrations. PCSK9 added to the regression model. Neither total cholesterol nor LDL‐C were significant risk factors in this study. Conclusions Proprotein convertase subtilisin kexin 9 concentrations are correlated with atheroma burden in Indian Asian populations from the sub‐continent, not taking statin therapy, independent of LDL‐C or other CVD risk factors.