Trends in pharmacological sciences (Regular ed.), 2015-07, Vol.36 (7), p.422-439
2015
Details
- Autor(en) / Beteiligte
- Titel
- FDA-approved small-molecule kinase inhibitors
- Ist Teil von
- Trends in pharmacological sciences (Regular ed.), 2015-07, Vol.36 (7), p.422-439
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2015
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • The classification of small-molecule kinase inhibitors is delineated. • All FDA-approved small-molecule kinase inhibitors (at April 2015) are presented according to binding mechanism and common structural features. • The current landscape and major challenges in kinase inhibition are discussed. • Possible future directions in developing novel kinase inhibitors are proposed.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0165-6147eISSN: 1873-3735DOI: 10.1016/j.tips.2015.04.005Titel-ID: cdi_proquest_miscellaneous_1692292580
- Format
- –
- Schlagworte
- Advanced Basic Science, cancer, crystal structure, Drug Approval, Enzyme Inhibitors - chemistry, Enzyme Inhibitors - pharmacology, lipid kinase, Models, Molecular, Molecular Structure, Phosphatidylinositol 3-Kinases - antagonists & inhibitors, Phosphatidylinositol 3-Kinases - chemistry, Phosphotransferases - antagonists & inhibitors, Phosphotransferases - chemistry, Protein Binding, protein kinase, Protein Kinase Inhibitors - chemistry, Protein Kinase Inhibitors - pharmacology, Protein-Serine-Threonine Kinases - antagonists & inhibitors, Protein-Serine-Threonine Kinases - chemistry, Protein-Tyrosine Kinases - antagonists & inhibitors, Protein-Tyrosine Kinases - chemistry, Receptor Protein-Tyrosine Kinases - antagonists & inhibitors, Receptor Protein-Tyrosine Kinases - chemistry, serine/threonine kinase, tyrosine kinase, United States, United States Food and Drug Administration