Details

Autor(en) / Beteiligte

• Tribulova, Narcis, PhD, DSc
• Szeiffova Bacova, Barbara, PhD
• Benova, Tamara, PhD
• Viczenczova, Csilla, MSc

Titel

Can we protect from malignant arrhythmias by modulation of cardiac cell-to-cell coupling?

Ist Teil von

• Journal of electrocardiology, 2015-05, Vol.48 (3), p.434-440

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2015

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• Abstract Defects in intercellular coupling in the heart play a key role in the initiation and persistence of malignant arrhythmias. Such disorders result from abnormal expression and distribution of connexins, the major constituents of cardiac gap junction channels. The alterations of myocardial connexin are well established as a consistent feature of both human and animal heart disease and aging. Following these facts, the modulation of connexin mediated intercellular coupling is suggested as a new antiarrhythmic approach. This review provides recent data supporting this concept. It can be challenging for the development of new antiarrhythmic drugs. Moreover, findings point out the implication of some endogenous compounds in protection from life-threatening arrhythmias via preservation of myocardial connexin.