Details

Autor(en) / Beteiligte

• Balamurugan, Dhayalan
• Muraleedharan, Kannoth M

Titel

Can Helical Peptides Unwind One Turn at a Time? - Controlled Conformational Transitions in α,β(2,3)-Hybrid Peptides

Ist Teil von

• Chemistry : a European journal, 2015-06, Vol.21 (26), p.9332-9338

Ort / Verlag

Germany

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Unfolding of helical trans-β(2,3) -hybrid peptides with (α-β)n α composition, when executed by increasing solvent polarity or temperature, proceeded in a systematic manner with the turns unwinding sequentially; C-terminal region of these peptides were first to unwind and the process propagated towards N terminus with more and more β residues equilibrating from the gauche to the anti rotameric state across Cα-Cβ . This is evidenced by clear change in their Cβ H signal splitting, (3)JCαH-CβH values, and sequential disappearance of i,i+2 NOEs.