Biomarkers in medicine, 2015-06, Vol.9 (6), p.563-575
2015
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Details
- Autor(en) / Beteiligte
- Titel
- Serum biomarkers predictive of pre-eclampsia
- Ist Teil von
- Biomarkers in medicine, 2015-06, Vol.9 (6), p.563-575
- Ort / Verlag
- England: Future Medicine Ltd
- Erscheinungsjahr
- 2015
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- We sought serum biomarkers predictive of pre-eclampsia (PE). : Sera obtained at 12-14 weeks of pregnancy from 24 cases who later developed PE and 24 controls with uncomplicated pregnancies were processed and analyzed using a serum proteomic approach. Many statistically significant serum PE biomarker candidates (n > 60) were found comparing cases and controls. In addition, logistic regression analysis modeled biomarker data resulted in 14 different multimarker combinations having high detection sensitivity and specificity (AUC >0.9). Developed panels of serum biomarkers appeared effective in identifying pregnant women at 12-14 weeks gestation at risk of PE later in their pregnancy.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1752-0363eISSN: 1752-0371DOI: 10.2217/bmm.15.21Titel-ID: cdi_proquest_miscellaneous_1689841108
- Format
- –
- Schlagworte
- Adult, Biological markers, Biomarkers, Biomarkers - blood, Blood pressure, Blood Proteins - metabolism, Diagnosis, early diagnosis, Female, Gynecology, Humans, Hypertension, Identification and classification, Lipids, Mass spectrometry, Methods, Molecular weight, Obstetrics, pre-eclampsia, Pre-Eclampsia - blood, Preeclampsia, Pregnancy, Proteins, Proteomics - methods, Scientific imaging, Sensitivity and Specificity, serum proteomics, Studies, Womens health