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American journal of clinical pathology, 2015-07, Vol.144 (1), p.94-96
Ort / Verlag
Oxford, UK: Oxford University Press
Erscheinungsjahr
2015
Quelle
Oxford Journals 2020 Medicine
Beschreibungen/Notizen
Objectives:
Anemia and thrombocytopenia are expected hematologic abnormalities in patients with acute babesiosis, whereas neutropenia (defined as an absolute neutrophil count of ≤1,800 neutrophils/μL for adults and <1,200 neutrophils/μL for infants) is not usually considered a feature of this infection. We studied the frequency with which neutropenia occurs in congenital and adult cases of babesiosis.
Methods:
The frequency of neutropenia in cases of congenital babesiosis was determined based on a literature review and on the findings in an unreported case. The frequency of neutropenia in adult patients was assessed based on a review of the medical records of 51 patients who were diagnosed with babesiosis between 2010 and 2013 at two medical centers in the Northeastern United States.
Results:
Four (80%; 95% confidence interval [CI], 36%–98%) of five infants with congenital babesiosis whose neutrophil count was reported were neutropenic. Among 51 adult cases with babesiosis, 11 (22%; 95% CI, 12%–35%) were neutropenic on clinical presentation, and seven others developed neutropenia over the next 1 to 21 days. Thus, a total of 18 (35%; 95% CI, 24%–49%) of the adult patients with babesiosis had neutropenia.
Conclusions:
Neutropenia appears to be a common finding in infants with congenital babesiosis and is also observed not infrequently in adults with this infection.