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Cyclophosphamide metabolite inducing apoptosis in RLS mouse lymphosarcoma cells is a substrate for P-glycoprotein
Ist Teil von
Bulletin of experimental biology and medicine, 2012, Vol.152 (3), p.348-352
Ort / Verlag
Boston: Springer US
Erscheinungsjahr
2012
Quelle
MEDLINE
Beschreibungen/Notizen
RLS lymphosarcoma characterized by enhanced expression of
mdr1a
and
mdr1b
genes encoding P-glycoprotein is insensitive to low doses of cyclophosphamide, but is susceptible to its high doses approximating the maximum tolerated doses. Induction of apoptotic death of RLS cells by high doses of cyclophosphamide was demonstrated by cytofl uorometry and electrophoresis. Experiments on RLS
40
tumor cells derived from RLS lymphosarcoma and characterized by more intensive expression of
mdr1a/1b
genes showed that the therapeutic effects of cyclophosphamide increased under conditions of simultaneous suppression of these genes by specifi c small interfering RNA (siRNA). These fi ndings suggest that active cyclophosphamide metabolite can be a substrate for P-glycoprotein.