Details

Autor(en) / Beteiligte

• Rodrigues, Natalia Camargo
• Brunelli, Roberta
• de Araújo, Heloísa Sobreiro Selistre
• Parizotto, Nivaldo Antonio
• Renno, Ana Claudia Muniz

Titel

Low-level laser therapy (LLLT) (660nm) alters gene expression during muscle healing in rats

Ist Teil von

• Journal of photochemistry and photobiology. B, Biology, 2013-03, Vol.120, p.29-35

Ort / Verlag

Switzerland: Elsevier B.V

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• ► We examine changes in the level of MRFs during muscle regeneration. ► Low-level laser therapy is able to decrease the mRNA Cox-2 levels. ► We report a cell response photo-induced. The effects of LLLT were studied during muscle regeneration through gene expression. It was evaluated 10 and 50J/cm2 doses during 7, 14 and 21days post cryoinjury, through histopathological analysis and mRNA MyoD, Myogenin, Vegf and Cox-2 expression. Irradiated groups presented less inflammatory process than control group after 14 and 21days. Cox-2 levels were downregulated in all irradiated groups after 7, 14 and 21days. On day 7, both treated groups had a downregulation of Vegf levels, and an upregulation after 14 and 21days, mainly with 50J/cm2. The MyoD levels were upregulated with high dose in all periods and with low dose after 21days. Myogenin expression was downregulated in both treated groups after 7days, and was upregulated with 10J/cm2 after 21days. These responses suggest that LLLT can improve the skeletal muscle regeneration through the gene expression stimulation.