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Chemokine (C-C Motif) Ligand 5 is Involved in Tumor-Associated Dendritic Cell-Mediated Colon Cancer Progression Through Non-Coding RNA MALAT-1
Journal of cellular physiology, 2015-08, Vol.230 (8), p.1883-1894
Kan, Jung-Yu
Wu, Deng-Chyang
Yu, Fang-Jung
Wu, Cheng-Ying
Ho, Ya-Wen
Chiu, Yen-Jung
Jian, Shu-Fang
Hung, Jen-Yu
Wang, Jaw-Yuan
Kuo, Po-Lin
2015
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Kan, Jung-Yu
Wu, Deng-Chyang
Yu, Fang-Jung
Wu, Cheng-Ying
Ho, Ya-Wen
Chiu, Yen-Jung
Jian, Shu-Fang
Hung, Jen-Yu
Wang, Jaw-Yuan
Kuo, Po-Lin
Titel
Chemokine (C-C Motif) Ligand 5 is Involved in Tumor-Associated Dendritic Cell-Mediated Colon Cancer Progression Through Non-Coding RNA MALAT-1
Ist Teil von
Journal of cellular physiology, 2015-08, Vol.230 (8), p.1883-1894
Ort / Verlag
United States: Blackwell Publishing Ltd
Erscheinungsjahr
2015
Quelle
Access via Wiley Online Library
Beschreibungen/Notizen
Tumor micro‐environment is a critical factor in the development of cancer. The aim of this study was to investigate the inflammatory cytokines secreted by tumor‐associated dendritic cells (TADCs) that contribute to enhanced migration, invasion, and epithelial‐to‐mesenchymal transition (EMT) in colon cancer. The administration of recombinant human chemokine (C‐C motif) ligand 5 (CCL5), which is largely expressed by colon cancer surrounding TADCs, mimicked the stimulation of TADC‐conditioned medium on migration, invasion, and EMT in colon cancer cells. Blocking CCL5 by neutralizing antibodies or siRNA transfection diminished the promotion of cancer progression by TADCs. Tumor‐infiltrating CD11c+ DCs in human colon cancer specimens were shown to produce CCL5. The stimulation of colon cancer progression by TADC‐derived CCL5 was associated with the up‐regulation of non‐coding RNA metastasis‐associated lung adenocarcinoma transcript 1 (MALAT‐1), which subsequently increased the expression of Snail. Blocking MALAT‐1 significantly decreased the TADC‐conditioned medium and CCL5‐mediated migration and invasion by decreasing the enhancement of Snail, suggesting that the MALAT‐1/Snail pathway plays a critical role in TADC‐mediated cancer progression. In conclusion, the inhibition of CCL5 or CCL5‐related signaling may be an attractive therapeutic target in colon cancer patients. J. Cell. Physiol. 230: 1883–1894, 2015. © 2014 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0021-9541
eISSN: 1097-4652
DOI: 10.1002/jcp.24918
Titel-ID: cdi_proquest_miscellaneous_1687673757
Format
–
Schlagworte
Cell Movement
,
Chemokine CCL5 - immunology
,
Chemokine CCL5 - metabolism
,
Colonic Neoplasms - genetics
,
Colonic Neoplasms - immunology
,
Colonic Neoplasms - pathology
,
Dendritic Cells - immunology
,
Dendritic Cells - metabolism
,
Disease Progression
,
Epithelial-Mesenchymal Transition - physiology
,
Fluorescent Antibody Technique
,
Humans
,
Oligonucleotide Array Sequence Analysis
,
Real-Time Polymerase Chain Reaction
,
Reverse Transcriptase Polymerase Chain Reaction
,
RNA, Long Noncoding - metabolism
,
RNA, Small Interfering
,
Transfection
,
Tumor Microenvironment - immunology
,
Tumors
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