Bulletin of experimental biology and medicine, 2013-03, Vol.154 (5), p.664-668
2013
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Mutagenic Activation Reduces Carcinogenic Activity of Ortho-Aminoazotoluene for Mouse Liver
- Ist Teil von
- Bulletin of experimental biology and medicine, 2013-03, Vol.154 (5), p.664-668
- Ort / Verlag
- Boston: Springer US
- Erscheinungsjahr
- 2013
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Pentachlorophenol (aromatic amine and azo stain metabolic stimulation inhibitor) reduced the hepatocarcinogenic activity of 4-aminoazobenzene and reduced that of ortho-aminoazotoluene in suckling mice. Both 4-aminoazobenzene and ortho-aminoazotoluene exhibited mutagenic activity in Ames’ test in vitro on S. typhimurium TA 98 strain with activation with liver enzymes; this mutagenic activity was similarly suppressed by adding pentachlorophenol into activation medium. Induction of xenobiotic metabolism enzymes, stimulating the mutagenic activity of ortho-aminoazotoluene, suppressed its carcinogenic effect on mouse liver. Hence, ortho-aminotoluene (the initial compound), but not its mutagenic metabolites, was the direct active hepatocarcinogen for mice.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0007-4888eISSN: 1573-8221DOI: 10.1007/s10517-013-2025-4Titel-ID: cdi_proquest_miscellaneous_1687662650
- Format
- –
- Schlagworte
- Animals, Biomedical and Life Sciences, Biomedicine, Carcinogenesis, Carcinogenicity Tests, Carcinogens - metabolism, Carcinogens - toxicity, Cell Biology, Enzymes, Internal Medicine, Laboratory Medicine, Liver, Liver - drug effects, Liver - metabolism, Male, Metabolites, Mice, Mice, Inbred C57BL, Mice, Inbred CBA, Mice, Inbred ICR, Mutagenicity Tests, o-Aminoazotoluene - chemistry, o-Aminoazotoluene - metabolism, o-Aminoazotoluene - toxicity, Pathology, Pentachlorophenol - chemistry, Pentachlorophenol - metabolism, Pentachlorophenol - pharmacology, Physiological aspects, Salmonella typhimurium, Xenobiotics