Details

Autor(en) / Beteiligte

• Chang, Ya-Ju, PhD
• Chou, Ching-Chieh, MS
• Huang, Wan-Ting, MS
• Lu, Chin-Song, MD
• Wong, Alice M., MD
• Hsu, Miao-Ju, PhD

Titel

Cycling Regimen Induces Spinal Circuitry Plasticity and Improves Leg Muscle Coordination in Individuals With Spinocerebellar Ataxia

Ist Teil von

• Archives of physical medicine and rehabilitation, 2015-06, Vol.96 (6), p.1006-1013

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Objectives To compare the reciprocal control of agonist and antagonist muscles in individuals with and without spinocerebellar ataxia (SCA) and to evaluate the effect of a 4-week leg cycling regimen on functional coordination and reciprocal control of agonist and antagonist muscles in patients with SCA. Design Randomized controlled trial with repeated measures. Setting Research laboratory in a general hospital. Participants Individuals with SCA (n=20) and without SCA (n=20). Interventions A single 15-minute session of leg cycling and a 4-week cycling regimen. Main Outcome Measures Individuals with SCA (n=20) and without SCA (n=20) underwent disynaptic reciprocal inhibition and D1 inhibition tests of the soleus muscles before and after a single 15-minute cycling session. Individuals with SCA were randomly assigned to either participate in 4 weeks of cycling training (n=10) or to receive no training (n=10). The disynaptic reciprocal inhibition and D1 inhibition and International Cooperative Ataxia Rating Scale (ICARS) scores were evaluated in both groups after 4 weeks. Results Individuals with SCA showed abnormally strong resting values of disynaptic reciprocal inhibition and D1 inhibition ( P <.001) and impaired inhibition modulation capacity after a single 15-minute session of cycling ( P <.001). The inhibition modulation capacity was restored ( P <.001), and the ICARS scores improved significantly (pre: 13.5±9.81, post: 11.3±8.74; P =.046) after 4 weeks of cycling training. Conclusions A 4-week cycling regimen can normalize the modulation of reciprocal inhibition and functional performance in individuals with SCA. These findings are applicable to the coordination training of patients.