Details

Autor(en) / Beteiligte

• Yi, Jin-Mu
• Kim, Jinhee
• Park, Jong-Shik
• Lee, Jun
• Lee, You Jin
• Hong, Jin Tae
• Bang, Ok-Sun
• Kim, No Soo

Titel

In Vivo Anti-tumor Effects of the Ethanol Extract of Gleditsia sinensis Thorns and Its Active Constituent, Cytochalasin H

Ist Teil von

• Biological and Pharmaceutical Bulletin, 2015/06/01, Vol.38(6), pp.909-912

Ort / Verlag

Japan: The Pharmaceutical Society of Japan

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Angiogenesis is the process of new vessel formation from pre-existing blood vasculature and is critical for continuous tumor growth. We previously reported that an ethanolic extract of Gleditsia sinensis thorns (EEGS) and its active constituent, cytochalasin H, have anti-angiogenic activity in vitro and in vivo via suppression of endothelial cell functions. In the present study, EEGS and cytochalasin H were observed to efficiently inhibit tumor growth in an in ovo xenograft model without significant toxicity. We repeatedly observed the anti-tumor and anti-metastatic effects of EEGS in representative animal models. These results suggest that EEGS and its active constituent, cytochalasin H, are potential candidates for the development of anti-angiogenic cancer drugs.