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Details

Autor(en) / Beteiligte
Titel
In Vivo Anti-tumor Effects of the Ethanol Extract of Gleditsia sinensis Thorns and Its Active Constituent, Cytochalasin H
Ist Teil von
  • Biological and Pharmaceutical Bulletin, 2015/06/01, Vol.38(6), pp.909-912
Ort / Verlag
Japan: The Pharmaceutical Society of Japan
Erscheinungsjahr
2015
Quelle
MEDLINE
Beschreibungen/Notizen
  • Angiogenesis is the process of new vessel formation from pre-existing blood vasculature and is critical for continuous tumor growth. We previously reported that an ethanolic extract of Gleditsia sinensis thorns (EEGS) and its active constituent, cytochalasin H, have anti-angiogenic activity in vitro and in vivo via suppression of endothelial cell functions. In the present study, EEGS and cytochalasin H were observed to efficiently inhibit tumor growth in an in ovo xenograft model without significant toxicity. We repeatedly observed the anti-tumor and anti-metastatic effects of EEGS in representative animal models. These results suggest that EEGS and its active constituent, cytochalasin H, are potential candidates for the development of anti-angiogenic cancer drugs.

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