Details

Autor(en) / Beteiligte

• Kiba, H
• Jayaraman, A

Titel

Nicotine induced c-fos expression in the striatum is mediated mostly by dopamine D sub(1) receptor and is dependent on NMDA stimulation

Ist Teil von

• Brain research. Molecular brain research., 1994-01, Vol.23 (1-2), p.1-13

Erscheinungsjahr

1994

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• The powerful psychostimulant and positive reinforcing effects of nicotine have been speculated to be mediated by the dopaminergic neurons of the ventral tegemental area (VTA) and their terminals in the nucleus accumbens. To extend our understanding of nicotine and dopamine interactions, we mapped the pattern of c-fos expression in the striatum as an important marker of some of the earliest changes that occur at gene transcription level. Acute nicotine injections in rats led to Fos expression more prominently in the caudatoputamen than in the nucleus accumbens in a dose-dependent fashion. Fos-reactive cells were more prominent in the central and dorsomedial limbic caudatoputamen than in the dorsolateral sensory-motor striatum. Nicotine induced Fos expression was also blocked completely by the NMDA receptor antagonists MK-801 and CPP. The results suggest that nicotine-induced Fos expression in the striatum is mediated mostly by dopamine D sub(1) receptors and that the Fos expression is also dependent on N-methyl-D-aspartate (NMDA) stimulation.