Details

Autor(en) / Beteiligte

• Weaver-Feldhaus, J
• Gruis, N A
• Neuhausen, S
• Le Paslier, D
• Stockert, E
• Skolnick, M H
• Kamb, A

Titel

Localization of a Putative Tumor Suppressor Gene by Using Homozygous Deletions in Melanomas

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 1994-08, Vol.91 (16), p.7563-7567

Ort / Verlag

United States: National Academy of Sciences of the United States of America

Erscheinungsjahr

1994

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• The p21 region of human chromosome 9 is thought to contain a gene (MLM) involved in genetic susceptibility to melanoma and a gene or genes that influence progression of certain other tumors. Genomic clones that span a large region in 9p21 surrounding the presumptive tumor suppressor gene(s) have been isolated. A set of sequence-tagged sites in this region has been developed. By using these markers and others previously reported, the 9p21 region has been studied by physical mapping in 84 melanoma cell lines. A putative tumor suppressor gene, perhaps MLM itself, has been localized to a region of less than 40 kb that lies proximal (centromeric) to the α-interferon gene cluster.