Details

Autor(en) / Beteiligte

• Manneganti, Vijay
• Bethala, Lakshmi Anu Prabhavathi Devi
• Rachapudi, Badari Narayana Prasad
• Singh, Ashita
• Ummanni, Ramesh

Titel

DESIGN, SYNTHESIS AND ANTICANCER ACTIVITIES OF NOVEL UNSATURATED FATTY ACID-BASED beta -HYDROXY 1,2,3-TRIAZOLES

Ist Teil von

• International journal of pharmaceutical sciences and research, 2015-04, Vol.6 (4), p.1635-1635

Erscheinungsjahr

2015

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• A series of novel unsaturated fatty acid based beta -hydroxy 1,2,3-triazole hybrids were designed and synthesised in excellent yields by esterification, epoxidation of oleic, ricinoleic and 10-undecenoic acids followed by azidolysis and "click" reaction with different alkynes. All the beta -hydroxy 1,2,3-triazole hybrids were characterised by ESI-MS, IR and NMR spectra as well as HRMS analysis and were screened in vitro for their anticancer activity against selected four human cancer cell lines (DU-145, HeLa, MCF-7 and A549) in comparison with doxorubicin, a standard anticancer drug. Among all the triazoles, methyl oleate with-CH sub( 2)OH as 1,2,3-triazole side chain (1dii) exhibited good anti cancer activity against DU-145, HeLa, MCF-7 and A549 human cancer cell lines with IC sub( 50) values 10.73, 13.61, 11.93, and 16.54 mu M respectively.