Details

Autor(en) / Beteiligte

• Bobbert, Thomas
• Schwarz, Franziska
• Fischer-Rosinsky, Antje
• Maurer, Lukas
• Möhlig, Matthias
• Pfeiffer, A.F.H.
• Mai, Knut
• Spranger, Joachim

Titel

Chemerin and prediction of Diabetes mellitus type 2

Ist Teil von

• Clinical endocrinology (Oxford), 2015-06, Vol.82 (6), p.838-843

Ort / Verlag

England: Blackwell Publishing Ltd

Erscheinungsjahr

2015

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Summary Objective Insulin resistance and subclinical inflammation are characteristics in the development of type 2 diabetes mellitus (T2DM). The adipokine chemerin has been associated with both factors. The aim of this study was to analyse whether chemerin predicts T2DM. Design Blood samples of 440 participants of the Metabolic‐Syndrome Berlin‐Potsdam (MesyBepo) follow‐up study without diabetes at baseline were available for chemerin measurement. Mean follow‐up of participants was 5·3 years. Glucose metabolism was analysed using oral glucose tolerance test including insulin measurements. Chemerin was measured using a commercially available ELISA. Results Thirty‐five individuals developed T2DM during follow‐up. Chemerin predicted incident T2DM (Chemerin 1. Tertile: reference, 2. Tertile: OR 2·33 [0·68–7·95]; Chemerin 3. Tertile: OR 3·42 [1·01–11·58] after adjustment for age, sex, BMI, follow‐up time, HbA1c, HOMA‐IR and WHR). In a secondary analysis, chemerin also predicted worsening of fasting glucose and HbA1c (adjusted for age, sex, BMI, time of follow‐up, WHR, HDL cholesterol and triglycerides). Conclusions Our data suggest that chemerin is a weak predictor of T2DM.