The New England journal of medicine, 1995-03, Vol.332 (12), p.774-778
1995
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Details
- Autor(en) / Beteiligte
- Titel
- Intrasphincteric Botulinum Toxin for the Treatment of Achalasia
- Ist Teil von
- The New England journal of medicine, 1995-03, Vol.332 (12), p.774-778
- Ort / Verlag
- Boston, MA: Massachusetts Medical Society
- Erscheinungsjahr
- 1995
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Achalasia is a disorder of esophageal motility characterized by the absence of peristalsis, an elevated pressure of the lower esophageal sphincter, and the failure of the lower esophageal sphincter to relax during swallowing. The usual treatment for achalasia — balloon dilation or myotomy of the lower esophageal sphincter — is aimed at lowering the resting pressure of the sphincter. 1 We hypothesized that locally injected botulinum toxin, a potent inhibitor of the release of acetylcholine from nerve endings, could be effective in the treatment of achalasia. This hypothesis was based on the concept that the net sphincter tone in the gut . . .
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0028-4793eISSN: 1533-4406DOI: 10.1056/NEJM199503233321203Titel-ID: cdi_proquest_miscellaneous_16820453
- Format
- –
- Schlagworte
- Achalasia, Adult, Aged, Biological and medical sciences, Botulinum toxin, Botulinum Toxins - therapeutic use, Clostridium botulinum, Diseases of the digestive system, Double-Blind Method, Drug therapy, Endoscopy, Endoscopy, Gastrointestinal, Esophageal Achalasia - physiopathology, Esophageal Achalasia - therapy, Esophageal sphincter, Esophagogastric Junction, Esophagus, Female, Follow-Up Studies, Gastroenterology, Humans, Injections, Male, Medical disorders, Medical research, Medical sciences, Middle Aged, Motility, Patients, Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects), Remission, Retention, Scintigraphy, Sensors, Sphincter, Swallowing, Throat