Bioorganic & medicinal chemistry letters, 2015-06, Vol.25 (11), p.2447-2451
2015
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Details
- Autor(en) / Beteiligte
- Titel
- Discovery of novel indirubin-3′-monoxime derivatives as potent inhibitors against CDK2 and CDK9
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2015-06, Vol.25 (11), p.2447-2451
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2015
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- [Display omitted] Indirubin-3′-monoxime (IM) is a potent cyclin-dependent kinase (CDK) inhibitor. Twenty novel IM derivatives were prepared to investigate the structure–activity relationships (SAR) of this compound class. Six compounds showed significant inhibition against both CDK2/cyclin E1 and CDK9/cyclin T1. The most potent compound 7t exhibited IC50 values at submicromolar level. Preliminary SAR trends were suggested and cytotoxicity of these compounds was investigated. Molecular docking studies on compounds 7l and 7t provided conducive clues for further structural optimization.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/j.bmcl.2015.03.066Titel-ID: cdi_proquest_miscellaneous_1680961092
- Format
- –
- Schlagworte
- Antineoplastic Agents - chemical synthesis, Antineoplastic Agents - pharmacology, Cell Line, Tumor, Cyclin-dependent kinase 2, Cyclin-Dependent Kinase 2 - adverse effects, Cyclin-dependent kinase 9, Cyclin-Dependent Kinase 9 - antagonists & inhibitors, Drug Discovery, Humans, Indirubin-3′-oxime derivatives, Indoles - chemistry, Models, Molecular, Molecular Structure, Oximes - chemistry, Structure-Activity Relationship