Details

Autor(en) / Beteiligte

• Laske, Christoph
• Stellos, Konstantinos
• Kempter, Ingrid
• Stransky, Elke
• Maetzler, Walter
• Fleming, Ingrid
• Randriamboavonjy, Voahanginirina

Titel

Increased cerebrospinal fluid calpain activity and microparticle levels in Alzheimer's disease

Ist Teil von

• Alzheimer's & dementia, 2015-05, Vol.11 (5), p.465-474

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2015

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Abstract Background Calpain has been associated with the pathophysiology of Alzheimer's disease (AD) and with apoptotic neuronal cell death leading to microparticles (MPs) formation. Methods A total of 64 patients with AD and 52 age- and gender-matched cognitively healthy elderly controls were included in the study. We measured calpain activity and levels of MPs, amyloid beta (Aβ1–42), h-tau, and p-tau181. Results AD patients showed significantly increased calpain activity and higher levels of MPs in cerebrospinal fluid (CSF) and significantly decreased calpain activity and lower levels of MPs in serum and plasma compared with healthy controls. Combined assessment of calpain activity and Aβ1–42 levels in CSF improved diagnostic accuracy as compared with singular or combined traditional CSF biomarkers of AD. Conclusions This is the first study showing increased calpain activity and microparticle levels in CSF of AD patients. Calpain activity could represent a novel diagnostic and prognostic biomarker and promising treatment target for AD.