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Molecular and serologic analysis in the transmission of the GB hepatitis agents
Journal of medical virology, 1995-05, Vol.46 (1), p.81-90
Schlauder, George G.
Dawson, George J.
Simons, John N.
Pilot-Matias, Tami J.
Gutierrez, Robin A.
Heynen, Cynthia A.
Knigge, Mark F.
Kurpiewski, Gretchen S.
Buijk, Sheri L.
Leary, Thomas P.
Muerhoff, A. Scott
Desai, Suresh M.
Mushahwar, Isa K.
1995
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Schlauder, George G.
Dawson, George J.
Simons, John N.
Pilot-Matias, Tami J.
Gutierrez, Robin A.
Heynen, Cynthia A.
Knigge, Mark F.
Kurpiewski, Gretchen S.
Buijk, Sheri L.
Leary, Thomas P.
Muerhoff, A. Scott
Desai, Suresh M.
Mushahwar, Isa K.
Titel
Molecular and serologic analysis in the transmission of the GB hepatitis agents
Ist Teil von
Journal of medical virology, 1995-05, Vol.46 (1), p.81-90
Ort / Verlag
New York: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
1995
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
Two flavivirus‐like genomes have recently been cloned fron infectious tamarin (Saguinus labiatus) serum, derived from the human viral hepatitis GB strain, which is known to induce hepatitits in tamarins. In order to study the natural history of GB infections, further transmission studies were carried out in tamarins. Reverse‐transcription‐polymerase chain reaction and enzymelinked immunosorbant assays were developedfor the detection of RNA and antibodies associated with the two agents, GB virus‐A and GB virus‐B. The infectivity of both of these agents was demonstrated in tamarins to be filterable through a 0.1 μm filter. Tow distinct genomes were identified in the serum of eight of the infected tamarins, while in four tamarins, the genomes were detected independently of each other. Although specific antibodies to the GB virus‐B epitopes were detected in the serum of animals inoculated with both agents or GB virus‐B alone, antibodies to putative epitopes specific to GB virus‐A were not detected in any of the animals. All tamarins inoculated with serum containing GB virus‐B exhibited an elevation in liver enzyme levels after inoculation. Elevations of serum liver enzyme levels did not occur when GB virus‐A was the only agent detected in the serum. Infection with the original infectious tamarin inoculum conferred protection from reinfection with GB virus‐B but not with GB virus‐A. © 1995 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0146-6615
eISSN: 1096-9071
DOI: 10.1002/jmv.1890460117
Titel-ID: cdi_proquest_miscellaneous_16803756
Format
–
Schlagworte
Animals
,
Antibodies, Viral - immunology
,
Base Sequence
,
Biological and medical sciences
,
ELISA
,
Enzyme-Linked Immunosorbent Assay
,
Epidemiology
,
Flavivirus - genetics
,
Flavivirus - isolation & purification
,
Flavivirus - pathogenicity
,
Fundamental and applied biological sciences. Psychology
,
GB agent
,
GBV-A
,
GBV-B
,
Hepatitis Viruses - genetics
,
Hepatitis Viruses - isolation & purification
,
Hepatitis Viruses - pathogenicity
,
Hepatitis, Viral, Animal - immunology
,
Hepatitis, Viral, Animal - transmission
,
Hepatitis, Viral, Animal - virology
,
Hepatitis, Viral, Human - immunology
,
Hepatitis, Viral, Human - transmission
,
Hepatitis, Viral, Human - virology
,
Human viral diseases
,
Humans
,
Infectious diseases
,
Liver - enzymology
,
Macaca
,
Medical sciences
,
Microbiology
,
Molecular Sequence Data
,
non-A
,
non-B
,
non-C
,
non-D
,
non-E hepatitis
,
PCR
,
Polymerase Chain Reaction
,
RNA, Viral - analysis
,
Saguinus
,
Saguinus labiatus
,
Viral diseases
,
Viral hepatitis
,
Virology
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