Details

Autor(en) / Beteiligte

• Vinogradov, Vasiliy V.
• Vinogradov, Alexander V.
• Sobolev, Vladimir E.
• Dudanov, Ivan P.
• Vinogradov, Vladimir V.

Titel

Plasminogen activator entrapped within injectable alumina: a novel approach to thrombolysis treatment

Ist Teil von

• Journal of sol-gel science and technology, 2015-02, Vol.73 (2), p.501-505

Ort / Verlag

Boston: Springer US

Erscheinungsjahr

2015

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A major obstacle in the development of new enzyme-based thrombolytic systems is their low stability and extremely short half-life (usually, less than 2–6 min of circulation half-life), which requires their administration in large doses to obtain therapeutic effects, and as a consequence, inevitably leads to a significant incidence of hemorrhagic complications. Here we point to a potential solution of this problem by developing a new family of injectable composites for thrombolysis: plasminogen activator entrapped within alumina, where alumina is a pertinent drug carrier developed to prolong activity in vivo and to reduce the total administered dose of the drug necessary for the treatment, and hence its side effects.