UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Ergebnis 16 von 35910
Datensatz exportieren als...
BibTeX
Determination of the in vivo degradation mechanism of PEGDA hydrogels
Journal of biomedical materials research. Part A, 2014-12, Vol.102 (12), p.4244-4251
Browning, M. B.
Cereceres, S. N.
Luong, P. T.
Cosgriff-Hernandez, E. M.
2014
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Browning, M. B.
Cereceres, S. N.
Luong, P. T.
Cosgriff-Hernandez, E. M.
Titel
Determination of the in vivo degradation mechanism of PEGDA hydrogels
Ist Teil von
Journal of biomedical materials research. Part A, 2014-12, Vol.102 (12), p.4244-4251
Ort / Verlag
Hoboken, NJ: Blackwell Publishing Ltd
Erscheinungsjahr
2014
Quelle
Wiley Blackwell Single Titles
Beschreibungen/Notizen
Poly(ethylene glycol) (PEG) hydrogels are one of the most extensively utilized biomaterials systems due to their established biocompatibility and highly tunable properties. It is widely acknowledged that traditional acrylate‐derivatized PEG (PEGDA) hydrogels are susceptible to slow degradation in vivo and are therefore unsuitable for long‐term implantable applications. However, there is speculation whether the observed degradation is due to hydrolysis of endgroup acrylate esters or oxidation of the ether backbone, both of which are possible in the foreign body response to implanted devices. PEG diacrylamide (PEGDAA) is a polyether‐based hydrogel system with similar properties to PEGDA but with amide linkages in place of the acrylate esters. This provides a hydrolytically‐stable control that can be used to isolate the relative contributions of hydrolysis and oxidation to the in vivo degradation of PEGDA. Here we show that PEGDAA hydrogels remained stable over 12 weeks of subcutaneous implantation in a rat model while PEGDA hydrogels underwent significant degradation as indicated by both increased swelling ratio and decreased modulus. As PEGDA and PEGDAA have similar susceptibility to oxidation, these results demonstrate for the first time that the primary in vivo degradation mechanism of PEGDA is hydrolysis of the endgroup acrylate esters. Additionally, the maintenance of PEGDAA hydrogel properties in vivo indicates their suitability for long‐term implants. These studies serve to elucidate key information about a widely used biomaterial system to allow for better implantable device design and to provide a biostable replacement option for PEGDA in applications that require long‐term stability. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 4244–4251, 2014.
Sprache
Englisch
Identifikatoren
ISSN: 1549-3296
eISSN: 1552-4965
DOI: 10.1002/jbm.a.35096
Titel-ID: cdi_proquest_miscellaneous_1677933956
Format
–
Schlagworte
Acrylates - chemistry
,
Acrylates - pharmacology
,
Animals
,
Biocompatibility
,
Biodegradable Plastics - chemistry
,
Biodegradable Plastics - pharmacology
,
Biological and medical sciences
,
Biomedical materials
,
Degradation
,
Esters
,
hydrogel
,
Hydrogels
,
Hydrogels - chemistry
,
Hydrogels - pharmacology
,
hydrolysis
,
in vivo degradation
,
In vivo testing
,
In vivo tests
,
Materials Testing
,
Medical sciences
,
Oxidation
,
poly(ethylene glycol)
,
Polyethylene Glycols - chemistry
,
Polyethylene Glycols - pharmacology
,
Rats
,
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
,
Surgical implants
,
Technology. Biomaterials. Equipments
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX