Details

Autor(en) / Beteiligte

• Oliveira, J. I. N.
• Albuquerque, E. L.
• Fulco, U. L.
• Mauriz, P. W.
• Sarmento, R. G.
• Caetano, E. W. S.
• Freire, V. N.

Titel

Conductance of single microRNAs chains related to the autism spectrum disorder

Ist Teil von

• Europhysics letters, 2014-09, Vol.107 (6), p.68006-p1-68006-p6

Ort / Verlag

EDP Sciences, IOP Publishing and Società Italiana di Fisica

Erscheinungsjahr

2014

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The charge transport properties of single-stranded microRNAs (miRNAs) chains associated to autism disorder were investigated. The computations were performed within a tight-binding model, together with a transfer matrix technique, with ionization energies and hopping parameters obtained by quantum chemistry method. Current-voltage curves of twelve miRNA chains related to the autism spectrum disorders were calculated and analysed. We have obtained both semiconductor and insulator behavior, and a relationship between the current intensity and the autism-related miRNA bases sequencies, suggesting that a kind of electronic biosensor can be developed to distinguish different profiles of autism disorders.