Details

Autor(en) / Beteiligte

• Mohr, Sharif B.
• Gorham, Edward D.
• Kim, June
• Hofflich, Heather
• Cuomo, Raphael E.
• Garland, Cedric F.

Titel

Could vitamin D sufficiency improve the survival of colorectal cancer patients?

Ist Teil von

• The Journal of steroid biochemistry and molecular biology, 2015-04, Vol.148, p.239-244

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2015

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• •A search was conducted for studies of serum 25(OH)D and colorectal cancer lethality.•A pooled hazard ratio was calculated from eligible studies.•Dose–response relationships were computed from eligible studies’ hazard ratios.•Higher levels of serum 25(OH)D were associated with lower colorectal cancer lethality.•Vitamin D sufficiency may improve survival of colorectal cancer patients. To determine whether a higher serum 25-hydroxyvitamin D [25(OH)D] concentration at diagnosis is associated with longer survival of colorectal cancer patients. A meta-analysis was performed of studies of the relationship between 25(OH)D and mortality of patients with colorectal cancer. A random-effects model was used to calculate a pooled hazards ratio. Homogeneity was evaluated through a DerSimonian–Laird test. Higher serum concentrations of 25(OH)D were associated with lower mortality in patients with colorectal cancer. Patients in the highest quintile of 25(OH)D had 37% lower mortality from colorectal cancer compared to those in the lowest quintile of 25(OH)D (pooled odds ratio=0.63, p<0.0001). Dose–response curves showed lower hazard ratios for mortality with higher serum 25(OH)D through at least 40ng/ml. There were no exceptions. Higher serum 25(OH)D was associated with lower mortality of patients with colorectal cancer. These results suggest that colorectal cancer patients with deficient levels of serum 25(OH)D should have their levels restored to a normal range (30–80ng/ml). This could be done with regular testing of serum 25(OH)D to be confident that an adequate serum level is being maintained. Additional studies would be worthwhile to evaluate confounding or the possibility of reverse causation.