Details

Autor(en) / Beteiligte

• Hendriksen, Ruben G F
• Hoogland, Govert
• Schipper, Sandra
• Hendriksen, Jos G M
• Vles, Johan S H
• Aalbers, Marlien W

Titel

A possible role of dystrophin in neuronal excitability: a review of the current literature

Ist Teil von

• Neuroscience and biobehavioral reviews, 2015-04, Vol.51, p.255-262

Ort / Verlag

United States

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Duchenne muscular dystrophy (DMD) is a recessive hereditary form of muscular dystrophy caused by a mutation in the dystrophin gene on the X chromosome. Clinical observations show that in addition to progressive muscular degeneration, DMD is more often accompanied by neurocognitive symptoms and learning disabilities, especially in automatisation of reading, attention processes, and expressive language skills. Additionally, three studies reported a higher prevalence of epilepsy in DMD, suggesting that the absence of dystrophin might be related to increased CNS excitability. In this article, we aim to review current clinical and experimental evidence for a potential role of brain dystrophin in seizure generation.