Details

Autor(en) / Beteiligte

• Nakano, Masahiko
• Suzuki, Hiroshi
• Imamura, Tadashi
• Lau, Annette
• Lynch, Barry

Titel

Genotoxicity of pyrroloquinoline quinone (PQQ) disodium salt (BioPQQ™)

Ist Teil von

• Regulatory toxicology and pharmacology, 2013-11, Vol.67 (2), p.189-197

Ort / Verlag

Netherlands: Elsevier Inc

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• •The genotoxic potential of BioPQQ™ was evaluated in a battery of genotoxicity tests.•BioPQQ™ did not display mutagenic properties in a reverse bacterial mutation assay.•BioPQQ™ tested negative in an in vitro chromosomal aberration test in human peripheral blood lymphocytes.•BioPQQ™ showed no genotoxic activity in an in vivo micronucleus assay in mice. The genotoxic potential of pyrroloquinoline quinone (PQQ) disodium salt (BioPQQ™) was evaluated in a battery of genotoxicity tests. The results of the bacterial mutation assay (Ames test) were negative. Weak positive results were obtained in 2 separate in vitro chromosomal aberration test in Chinese hamster lung (CHL) fibroblasts. Upon testing in an in vitro chromosomal aberration test in human peripheral blood lymphocytes, no genotoxic activity of PQQ was noted. In the in vivo micronucleus assay in mice, PQQ at doses up to 2000mg/kg body weight demonstrated that no genotoxic effects are expressed in vivo in bone marrow erythrocytes. The weak responses in the in vitro test CHL cells were considered of little relevance under conditions of likely human exposure. PQQ disodium was concluded to have no genotoxic activity in vivo.