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Amino acid mutations in Ebola virus glycoprotein of the 2014 epidemic
Journal of medical virology, 2015-06, Vol.87 (6), p.893-898
Giovanetti, Marta
Grifoni, Alba
Lo Presti, Alessandra
Cella, Eleonora
Montesano, Carla
Zehender, Gianguglielmo
Colizzi, Vittorio
Amicosante, Massimo
Ciccozzi, Massimo
2015
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Giovanetti, Marta
Grifoni, Alba
Lo Presti, Alessandra
Cella, Eleonora
Montesano, Carla
Zehender, Gianguglielmo
Colizzi, Vittorio
Amicosante, Massimo
Ciccozzi, Massimo
Titel
Amino acid mutations in Ebola virus glycoprotein of the 2014 epidemic
Ist Teil von
Journal of medical virology, 2015-06, Vol.87 (6), p.893-898
Ort / Verlag
United States: Blackwell Publishing Ltd
Erscheinungsjahr
2015
Quelle
Wiley Online Library All Journals
Beschreibungen/Notizen
Zaire Ebola virus (EBOV) is an enveloped non‐segmented negative strand RNA virus of 19 kb in length belonging to the family Filoviridae. The virus was isolated and identified in 1976 during the epidemic of hemorrhagic fever in Zaire. The most recent outbreak of EBOV among humans, was that occurred in the forested areas of south eastern Guinea, that began in February 2014 and is still ongoing. The recent Ebola outbreak, is affecting other countries in West Africa, in addiction to Guinea: Liberia, Nigeria, and Sierra Leone. In this article, a selective pressure analysis and homology modeling based on the G Glycoprotein (GP) sequences retrieved from public databases were used to investigate the genetic diversity and modification of antibody response in the recent outbreak of Ebola Virus. Structural and the evolutionary analysis underline the 2014 epidemic virus being under negative selective pressure does not change with respect to the old epidemic in terms of genome adaptation. J. Med. Virol. 87:893–898, 2015. © 2015 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0146-6615
eISSN: 1096-9071
DOI: 10.1002/jmv.24133
Titel-ID: cdi_proquest_miscellaneous_1676359571
Format
–
Schlagworte
Africa, Western - epidemiology
,
Amino acids
,
Amino Acids - genetics
,
Antibodies, Neutralizing - immunology
,
Antibodies, Viral - immunology
,
Databases, Factual
,
Databases, Nucleic Acid
,
Datasets as Topic
,
Ebola virus
,
Ebolavirus - chemistry
,
Ebolavirus - genetics
,
Epidemics
,
Epidemiology
,
evolutionary analysis
,
Filoviridae
,
Genetic Variation
,
glycoprotein
,
Glycoproteins
,
Hemorrhagic Fever, Ebola - epidemiology
,
Hemorrhagic Fever, Ebola - virology
,
Humans
,
Models, Molecular
,
Mutation
,
Selection, Genetic
,
Time Factors
,
Viral Envelope Proteins - chemistry
,
Viral Envelope Proteins - genetics
,
Viral Envelope Proteins - immunology
,
Virology
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