Details

Autor(en) / Beteiligte

• Sun, Mingli
• Pang, Lei
• Ju, Xuepeng
• Sun, Haigang
• Yu, Jiankun
• Zhao, Haishan
• Yao, Weifan
• Wei, Minjie

Titel

Attenuating effects of omega-3 fatty acids (Omegaven) on irradiation-induced intestinal injury in mice

Ist Teil von

• Food and chemical toxicology, 2014-02, Vol.64, p.275-280

Ort / Verlag

Oxford: Elsevier Ltd

Erscheinungsjahr

2014

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• •Omegaven was shown to improve survival of irradiated mice.•Omegaven presented a protective effect on irradiation-induced intestinal injury in mice.•Omegaven presented a protective effect on irradiation-induced myelosuppression in mice.•Omegaven presented antioxidant and antiinflammatory effect in irradiated mice. Gastrointestinal injury is a major cause of death following exposure to high levels of irradiation, and no effective treatments are currently available. In this study, we examined the effect of omega-3 fatty acids (Omegaven) on intestinal injury of BALB/c mice induced by irradiation. Intravenously administered 3days prior to irradiation for 7 consecutive days, Omegaven was shown to improve survival, intestinal morphology including villous height, crypt height and mucosal thickness and the intestinal proliferation compared with saline control. Omegaven also normalized the levels of circulating tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6), attenuated the increase of diamino oxidase (DAO) activity and malondialdehyde (MDA) level and recovered the decrease of superoxide dismutase (SOD) activity. Meanwhile, Omegaven attenuated the myelosuppression caused by irradiation. In conclusion, our results suggest that Omegaven enhanced the survival of irradiated mice and minimized the effects of radiation on gastrointestinal injury.