Details

Autor(en) / Beteiligte

• Leal, Mariana Ferreira
• Antunes, Lusânia Maria Greggi
• Lamarão, Maria Fernanda Vita
• da Silva, Carla Elvira Araújo
• da Silva, Ismael Dale Cotrim Guerreiro
• Assumpção, Paulo Pimentel
• Andrade, Edilson Ferreira
• Rezende, Alexandre Pingarilho
• Imbeloni, Aline Amaral
• Muniz, José Augusto Pereira Carneiro
• Pinto, Giovanny Rebouças
• Smith, Marília de Arruda Cardoso
• Burbano, Rommel Rodríguez

Titel

The protective effect of Canova homeopathic medicine in cyclophosphamide-treated non-human primates

Ist Teil von

• Food and chemical toxicology, 2012-12, Vol.50 (12), p.4412-4420

Ort / Verlag

Oxford: Elsevier Ltd

Erscheinungsjahr

2012

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• ► We evaluated Canova effects on non-human primate treated with cyclophosphamide. ► Cyclophosphamide induced abnormal WBC count, micronucleus and DNA damage in all animals. ► Canova treated animals presented a higher leukocyte count than the animals without this treatment. ► Animals treated with Canova presented lower frequency of micronucleus and DNA damage than animals without this medicine. ► Canova treatment minimizes cyclophosphamide myelotoxicity in Cebus apella. Background: Canova activates macrophages and indirectly induces lymphocyte proliferation. Here we evaluated the effects of Canova in cyclophosphamide-treated non-human primates. Methods: Twelve Cebus apella were evaluated. Four animals were treated with Canova only. Eight animals were treated with two doses of cyclophosphamide (50mg/kg) and four of these animals received Canova. Body weight, biochemistry and hematologic analyses were performed for 40days. Micronucleus and comet assays were performed for the evaluation of DNA damage. Results: We observed that cyclophosphamide induced abnormal WBC count in all animals. However, the group treated with cyclophosphamide plus Canova presented a higher leukocyte count than that which received only cyclophosphamide. Cyclophosphamide induced micronucleus and DNA damage in all animals. The frequency of these alterations was significantly lower in the Canova group than in the group without this medicine. Conclusions: Our results demonstrated that Canova treatment minimizes cyclophosphamide myelotoxicity in C. apella.