Details

Autor(en) / Beteiligte

• Schosserer, M
• Grubeck-Loebenstein, B
• Grillari, J

Titel

Principles of biological aging

Ist Teil von

• Zeitschrift für Gerontologie und Geriatrie, 2015-04, Vol.48 (3), p.285-294

Ort / Verlag

Germany

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• The aging process is the substrate on which aging-associated diseases develop; therefore, the scientific discipline of gerontology aims at understanding this biological aging process, which refers to the progressive increase in the risk of death caused by a loss of body functions. Studies in simple model organisms demonstrate that pharmacological substances, genetic interventions and dietary restriction can slow down the process of aging. The cell culture model of cellular senescence gives researchers the opportunity to conduct studies in a system more closely related to the human organism; therefore, cells from different human tissues are cultured in vitro until they stop proliferating. This permanent growth arrest is called cellular senescence. Recent studies have demonstrated that senescent cells also accumulate in many tissues in vivo and contribute to age-related pathologies.