Trends in pharmacological sciences (Regular ed.), 2015-03, Vol.36 (3), p.172-180
2015
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Details
- Autor(en) / Beteiligte
- Titel
- Unravelling adverse reactions to NSAIDs using systems biology
- Ist Teil von
- Trends in pharmacological sciences (Regular ed.), 2015-03, Vol.36 (3), p.172-180
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2015
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • The underlying mechanisms of adverse drug reactions (ADRs) are not fully understood. • Systems biology may help piece together genetic, transcriptomic, and epigenetic data. • Such methods can help find novel genes for further study and prioritise putative SNPs. • Examples include the use of gene networks and searches for SNPs that affect expression.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0165-6147eISSN: 1873-3735DOI: 10.1016/j.tips.2014.12.003Titel-ID: cdi_proquest_miscellaneous_1675871158
- Format
- –
- Schlagworte
- Advanced Basic Science, adverse drug reactions, Anti-Inflammatory Agents, Non-Steroidal - adverse effects, Drug Hypersensitivity - etiology, Drug Hypersensitivity - genetics, Drug Hypersensitivity - metabolism, functional genomics, high-throughput data, Humans, hypersensitivity drug reaction, nonsteroidal anti-inflammatory drugs (NSAIDs), NSAIDs-hypersensitivity, Protein Interaction Maps, Systems Biology