Details

Autor(en) / Beteiligte

• Brassai, A
• Suvanjeiev, R.-G
• Bán, E.-Gy
• Lakatos, M

Titel

Role of synaptic and nonsynaptic glutamate receptors in ischaemia induced neurotoxicity

Ist Teil von

• Brain research bulletin, 2015-03, Vol.112, p.1-6

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Highlights • Ischaemic brain injury leads to excitotoxicity and cell death. • The glutamatergic transmission via synaptic NMDA receptors is neuroprotective. • Non-synaptic NMDA receptors (composed of GluN2B subunits) are excitotoxic. • Selective inhibition of non-synaptic NMDARs may be beneficial. • Oxygen–glucose deprivation mimics ischaemic conditions.