Details

Autor(en) / Beteiligte

• Ferreira-Julio, Maysa Araujo
• Pinhel, Marcela Souza
• Quinhoneiro, Driele Cristina Gomes
• Nicoletti, Carolina Ferreira
• Brandão, Antonio Carlos
• Nonino, Carla Barbosa
• Pinheiro, Jr, Sidney
• Oliveira, Bruno Affonso Parenti
• Gregório, Michele Lima
• Andrade, Days Oliveira
• Cortes-Oliveira, Cristiana
• Souza, Dorotéia Silva

Titel

LEP -2548G>A Polymorphism of the Leptin Gene and Its Influence on the Lipid Profile in Obese Individuals

Ist Teil von

• Journal of nutrigenetics and nutrigenomics, 2014, Vol.7 (4-6), p.225-231

Ort / Verlag

Switzerland

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• We studied the molecular pathogenesis of obesity, involving complex interactions between environmental and genetic factors, with a focus on the leptin gene. It was our aim to characterize the LEP -2548G>A leptin polymorphism and lipid profile in obese and normal-weight individuals. A total of 212 individuals were divided into the study group including 136 obese patients (body mass index, BMI≥30) and the control group with 76 normal-weight individuals (BMI>18.5 and ≤24.9). DNA was amplified by polymerase chain reaction and restriction fragment length polymorphism. The lipid profile was analyzed by enzymatic colorimetric methods. The level of significance was set at p<0.05. There was a prevalence of the GA genotype in both groups. However, comparative group analysis showed an association of the recessive model (AA+GA) with increased triglycerides (TG) and decreased high-density lipoprotein cholesterol (HDL-C) levels in the study group. This study did not confirm an association between obesity and the LEP -2548G>A polymorphism. However, AA+GA genotypes, in the presence of obesity, seem to contribute to a reduction in HDL-C and an increase in TG compared with normal-weight individuals. This should be confirmed in further studies.