General and comparative endocrinology, 2014-10, Vol.207, p.74-85
2014
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Details
- Autor(en) / Beteiligte
- Titel
- Production, gene structure and characterization of two orthologs of leptin and a leptin receptor in tilapia
- Ist Teil von
- General and comparative endocrinology, 2014-10, Vol.207, p.74-85
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2014
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • Using synteny, the tLeps were found near common genes. • 3D structures of tLepA and tLepB predicted strong conservation with that of human. • tLeps were biologically active in promoting proliferation of BAF/3 cells. • tLeps promoted STAT-LUC activation through tLepR but not through hLepR. • Expression of brain tLepA, tLepB or tLepR, were similar between fed and fast fish.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0016-6480eISSN: 1095-6840DOI: 10.1016/j.ygcen.2014.05.006Titel-ID: cdi_proquest_miscellaneous_1673394544
- Format
- –
- Schlagworte
- Amino Acid Sequence, Animals, Base Sequence, DNA, Complementary - genetics, Endocrinology & Metabolism, Escherichia coli, Fish Proteins - chemistry, Fish Proteins - genetics, Fish Proteins - metabolism, High-Throughput Nucleotide Sequencing, Humans, Leptin - metabolism, Mice, Molecular Sequence Data, Oreochromis niloticus, Phylogeny, Plasmids - genetics, Protein Structure, Secondary, Real-Time Polymerase Chain Reaction, Receptors, Leptin - genetics, Receptors, Leptin - metabolism, Recombinant leptin, Recombinant Proteins - genetics, Recombinant Proteins - metabolism, Reverse Transcriptase Polymerase Chain Reaction, RNA, Messenger - genetics, RNA-seq, Sequence Homology, Amino Acid, STAT3, Synteny, Tilapia, Tilapia - physiology