Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Do Biologic Parameters Affect the Time to First Treatment of Clinical Monoclonal B-Cell Lymphocytosis and Chronic Lymphocytic Leukemia Rai Stage 0? Results of a Prospective Analysis
Ist Teil von
Clinical lymphoma, myeloma and leukemia, 2015-03, Vol.15 (3), p.e55-e60
Ort / Verlag
United States: Elsevier Inc
Erscheinungsjahr
2015
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Micro-Abstract We investigated the clinical relevance of classic and new prognostic markers, immunoglobulin heavy-chain variable (IGHV) gene mutational status, and chromosomal abnormalities in clinical monoclonal B lymphocytosis (cMBL) compared with chronic lymphocytic leukemia (CLL), Rai stage 0. In our prospective patient cohort, we have confirmed that IGHV mutation status appeared to be the best predictor of the time to first treatment in patients with cMBL/CLL Rai stage 0. In addition, when associated with the B-cell count, IGHV mutational status might help to better stratify patients into more precise subgroups.