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Ehlers–Danlos Syndrome Associated with Fatal Spontaneous Vascular Rupture in a Dog
Ist Teil von
Journal of comparative pathology, 2015-02, Vol.152 (2-3), p.211-216
Ort / Verlag
England: Elsevier Ltd
Erscheinungsjahr
2015
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
A 7-month-old male cross breed dog was presented with hyperextensible skin and atrophic scarring. A diagnosis of Ehlers–Danlos syndrome was made based on clinical signs, histopathology and electron microscopy. Two weeks after presentation, the dog died suddenly. Post-mortem examination revealed haemothorax and rupture of the left subclavian artery. Histological findings, including Goldner's modified Masson's trichrome staining and transmission electron microscopy of the subclavian artery, revealed abnormalities in the structure and arrangement of collagen fibrils, suggesting that the defective collagen formation extended to the vasculature. To the authors' knowledge, this is the first report of Ehlers–Danlos syndrome with vascular involvement in animals.