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The effects of bilateral bipolar sacral neurostimulation on urinary bladder activity during filling before and after irritation in a rat model
Neurourology and urodynamics, 2015-04, Vol.34 (4), p.387-391
Dieter, Alexis A.
Degoski, Danielle J.
Dolber, Paul C.
Fraser, Matthew O.
2015
Details
Autor(en) / Beteiligte
Dieter, Alexis A.
Degoski, Danielle J.
Dolber, Paul C.
Fraser, Matthew O.
Titel
The effects of bilateral bipolar sacral neurostimulation on urinary bladder activity during filling before and after irritation in a rat model
Ist Teil von
Neurourology and urodynamics, 2015-04, Vol.34 (4), p.387-391
Ort / Verlag
United States: Blackwell Publishing Ltd
Erscheinungsjahr
2015
Link zum Volltext
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
Aims To design an optimal rat model for studying sacral neurostimulation (SNS), and examine the effect of SNS on myogenic non‐voiding contractions (NVC) during filling before and after intraluminal irritation. Methods Bilateral paired bipolar SNS was performed in 10 female urethane anesthetized Sprague–Dawley rats at the L6–S1 trunks at 10 Hz, 0.1 msec pulse duration and 0.15–0.80 mA (below motor threshold). Transvesical cystometry was performed before and during SNS under conditions of control (saline, N = 10) and irritation [0.25% acetic acid (AA), N = 5]. Results Functional bladder capacity (FBC) and NVC count were significantly increased during SNS under both control and irritation conditions (P < 0.01 for all). In six instances (four in control, two in irritation), micturition reflexes were completely inhibited by SNS resulting in overflow incontinence. Filling compliance, NVC period and NVC maximum amplitude were not affected by SNS (P > 0.05 for all). Non‐parametric two‐way analysis of variance for repeated measures revealed increased FBC and NVC count during SNS under both control and irritation conditions (P = 0.004 for both, N = 5 rats). Linear regression analysis of NVC count versus FBC revealed a slope significantly different than zero, independent of control or irritation conditions (slope 33.10 ± 2.43, R2 = 0.81, P < 0.001). Conclusions This model achieved reliable, reversible and robust increases in bladder capacity up to overflow incontinence at stimulations below somatic motor threshold. SNS dramatically increased FBC and reversed AA‐induced changes without affecting the character of normal NVC associated with bladder filling. Increased number of NVC is simply a consequence of increased fill time. Neurourol. Urodynam. 34:387–391, 2015. © 2014 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0733-2467
eISSN: 1520-6777
DOI: 10.1002/nau.22556
Titel-ID: cdi_proquest_miscellaneous_1673072235
Format
–
Schlagworte
Acetic Acid
,
Animals
,
Disease Models, Animal
,
Female
,
neurophysiology
,
non-voiding contractions
,
overactive
,
rats
,
Rats, Sprague-Dawley
,
Reflex
,
Spinal Cord Stimulation - methods
,
Time Factors
,
urinary bladder
,
Urinary Bladder - innervation
,
Urinary Bladder, Overactive - chemically induced
,
Urinary Bladder, Overactive - physiopathology
,
Urinary Bladder, Overactive - therapy
,
Urinary Incontinence - chemically induced
,
Urinary Incontinence - physiopathology
,
Urinary Incontinence - therapy
,
Urination
,
Urodynamics
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