Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Protective Activity of Silipide on Liver Damage in Rodents
Ist Teil von
The Japanese Journal of Pharmacology, 1992, Vol.60(4), pp.315-321
Ort / Verlag
Kyoto: The Japanese Pharmacological Society
Erscheinungsjahr
1992
Quelle
MEDLINE
Beschreibungen/Notizen
The activity of silipide, a silybin-phosphatidylcholine complex (IdB 1016), was tested in different models of liver damage in rodents. After oral administration, silipide exhibited a significant and dose-related protective effect against the hepatotoxicity induced by CC14, praseodymium, ethanol and galactosamine. The ED50 values for inhibition of the rise in ASAT and ALAT levels caused by CC14 and praseodymium and for antagonism of the increase in liver triglycerides caused by ethanol ranged from 93 to 156mg/kg (as silybin). At a dose of 400mg/kg (as silybin), silipide was also active in protecting against paracetamol-induced hepatotoxicity. Silybin and phosphatidylcholine at doses equivalent to those contained in the active doses of silipide failed to show any significant protective activity in these models. The liver protective effect of silipide is probably related to its antioxidant activities and to a stimulating effect on the hepatic synthesis of RNA and proteins.