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Weighted Logrank Permutation Tests for Randomly Right Censored Life Science Data
Ist Teil von
Scandinavian journal of statistics, 2014-09, Vol.41 (3), p.742-761
Ort / Verlag
Oxford: Blackwell Publishing Ltd
Erscheinungsjahr
2014
Link zum Volltext
Quelle
EBSCOhost Business Source Ultimate
Beschreibungen/Notizen
In biomedical research, weighted logrank tests are frequently applied to compare two samples of randomly right censored survival times. We address the question how to combine a number of weighted logrank statistics to achieve good power of the corresponding survival test for a whole linear space or cone of alternatives, which are given by hazard rates. This leads to a new class of semiparametric projection tests that are motivated by likelihood ratio tests for an asymptotic model. We show that these tests can be carried out as permutation tests and discuss their asymptotic properties. A simulation study together with the analysis of a classical data set illustrates the advantages.