Details

Autor(en) / Beteiligte

• Serra, Aida
• Macià, Alba
• Romero, Maria-Paz
• Anglés, Neus
• Morelló, Jose-Ramón
• Motilva, Maria-José

Titel

Metabolic pathways of the colonic metabolism of procyanidins (monomers and dimers) and alkaloids

Ist Teil von

• Food chemistry, 2011-06, Vol.126 (3), p.1127-1137

Ort / Verlag

Kidlington: Elsevier Ltd

Erscheinungsjahr

2011

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• ► Procyanidins are catabolised after 24–48h of colonic fermentation. ► Qualitative and cuantitative differences are observed between colonic fermentation of catechin and epicatechin. ► Alkaloids are not metabolized by the colonic microflora. Procyanidins are metabolised by endogenous gastrointestinal microflora into several small molecules that may exert systemic effects. However, the metabolic pathways of procyanidins are still largely uncharacterised. The aim of this study was to evaluate the colonic metabolism of procyanidins (catechin, epicatechin, epicatechin gallate, epigallocatechin gallate and dimer B2) and alkaloids (theobromine and caffeine) by an in vitro colonic fermentation model using rat colonic microflora. Simultaneously, a nuts-cocoa cream was incubated and the colonic metabolism of procyanidins and alkaloids was evaluated. Results showed that most of the procyanidins tested were catabolised after 24–48h of fermentation. Fermentation of the dimer B2 did not produce the same catabolic compounds as epicatechin fermentation and differences were observed between the fermentation of catechin and epicatechin. The alkaloids were not metabolised by the colonic microflora and this fact was verified in vivo. The results showed an intense metabolism of procyanidins and poor metabolism of alkaloids.