Lung cancer (Amsterdam, Netherlands), 2015-05, Vol.88 (2), p.154-159
2015
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Details
- Autor(en) / Beteiligte
- Titel
- Immunohistochemical status of PD-L1 in thymoma and thymic carcinoma
- Ist Teil von
- Lung cancer (Amsterdam, Netherlands), 2015-05, Vol.88 (2), p.154-159
- Ort / Verlag
- Ireland: Elsevier Ireland Ltd
- Erscheinungsjahr
- 2015
- Quelle
- ScienceDirect
- Beschreibungen/Notizen
- Highlights • PD-L1 stained positive for 70% of thymic carcinomas and 23% of thymomas. • The PD-L1 antibody in our study was validated with knock-down cell lines. • PD-L1 expressed more frequently in thymic carcinomas than in thymomas. • Expression of PD-L1 was not a significant negative factor of overall survival. • Our study suggested potential use of the anti PD-1/PD-L1 drugs for thymic cancers.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0169-5002eISSN: 1872-8332DOI: 10.1016/j.lungcan.2015.03.003Titel-ID: cdi_proquest_miscellaneous_1671220581
- Format
- –
- Schlagworte
- Adult, Aged, Aged, 80 and over, Antibodies, Monoclonal - metabolism, B7-H1 Antigen - metabolism, Cell Line, Tumor, Clone E1L3N, Female, Hematology, Oncology and Palliative Medicine, Humans, Immunohistochemistry, Immunohistochemistry - methods, Male, Middle Aged, PD-1, PD-L1, Programmed Cell Death 1 Receptor - metabolism, Pulmonary/Respiratory, Thymic carcinoma, Thymoma, Thymoma - metabolism, Thymoma - pathology, Thymus Neoplasms - metabolism, Thymus Neoplasms - pathology