Details

Autor(en) / Beteiligte

• Alò, Raffaella
• Avolio, Ennio
• Mele, Maria
• Di Vito, Anna
• Canonaco, Marcello

Titel

Central amygdalar nucleus treated with orexin neuropeptides evoke differing feeding and grooming responses in the hamster

Ist Teil von

• Journal of the neurological sciences, 2015-04, Vol.351 (1), p.46-51

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2015

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• Abstract Interaction of the orexinergic (ORXergic) neuronal system with the excitatory (glutamate, l -Glu) or the inhibitory (GABA) neurosignaling complexes evokes major homeostatic physiological events. In this study, effects of the two ORXergic neuropeptides (ORX-A/B) on their receptor (ORX-2R) expression changes were correlated to feeding and grooming actions of the hibernating hamster ( Mesocricetus auratus ). Infusion of the central amygdala nucleus (CeA) with ORX-A caused hamsters to consume notable quantities of food, while ORX-B accounted for a moderate increase. Interestingly the latter neuropeptide was responsible for greater frequencies of grooming with respect to both controls and the hamsters treated with ORX-A. These distinct behavioral changes turned out to be even greater in the presence of l -Glu agonist (NMDA) while the α1 GABAA receptor agonist (zolpidem, Zol) greatly reduced ORX-A-dependent feeding bouts. Moreover, ORX-A + NMDA mainly promoted greater ORX-2R expression levels with respect to ORX-A-treated hamsters while ORX-B + Zol was instead largely responsible for a down-regulatory trend. Overall, these features point to CeA ORX-2R sites as key sensory limbic elements capable of regulating eating and grooming responses, which may provide useful insights regarding the type of molecular mechanism(s) operating during feeding bouts.