Advanced materials (Weinheim), 2015-03, Vol.27 (9), p.1567-1572
2015
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Spatially Gradated Hydrogel Platform as a 3D Engineered Tumor Microenvironment
- Ist Teil von
- Advanced materials (Weinheim), 2015-03, Vol.27 (9), p.1567-1572
- Ort / Verlag
- Germany: Blackwell Publishing Ltd
- Erscheinungsjahr
- 2015
- Quelle
- Access via Wiley Online Library
- Beschreibungen/Notizen
- There is an acute need for biomaterial tools that recreate the heterogeneous brain‐tumor microenvironment. A microfluidic mixing tool is reported to encapsulate glioblastoma multiforme cells within miniaturized gelatin hydrogels containing overlapping patterns of tumor‐inspired matrix signals. This approach permits in situ analysis of glioma cells at the molecular and genomic level as well as the potential for clinical insight.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0935-9648eISSN: 1521-4095DOI: 10.1002/adma.201404896Titel-ID: cdi_proquest_miscellaneous_1669861047
- Format
- –
- Schlagworte
- Biomaterials, Biomedical materials, Biomimetic Materials, Cell Count, Cell Line, Tumor, Encapsulation, Gelatin, Gene Expression, glioblastoma, Glioblastoma - metabolism, Glioblastoma - pathology, gradient, Humans, hydrogel, Hydrogels, Microfluidics, Microfluidics - methods, Platforms, Surgical implants, Three dimensional, Tissue Engineering - methods, Tumor Microenvironment