Details

Autor(en) / Beteiligte

• Rachid, Tamiris Lima
• Penna-de-Carvalho, Aline
• Bringhenti, Isabele
• Aguila, Marcia B.
• Mandarim-de-Lacerda, Carlos A.
• Souza-Mello, Vanessa

Titel

Fenofibrate (PPARalpha agonist) induces beige cell formation in subcutaneous white adipose tissue from diet-induced male obese mice

Ist Teil von

• Molecular and cellular endocrinology, 2015-02, Vol.402, p.86-94

Ort / Verlag

Ireland: Elsevier Ireland Ltd

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• •PPARgamma has been associated with white-brown adipocyte plasticity.•We evaluated whether fenofibrate could induce beige cell depots in obese mice.•Fenofibrate yielded UCP-1-positive beige cells in subcutaneous white adipose tissue.•Beige cells markedly expressed genes typically found in the brown adipose tissue.•Irisin and PPARalpha interplay might orchestrate this pathway. Browning is characterized by the formation of beige/brite fat depots in subcutaneous white adipose tissue (sWAT). This study aimed to examine whether the chronic activation of PPARalpha by fenofibrate could induce beige cell depots in the sWAT of diet-induced obese mice. High-fat fed animals presented overweight, insulin resistance and displayed adverse sWAT remodeling. Fenofibrate significantly attenuated these parameters. Treated groups demonstrated active UCP-1 beige cell clusters within sWAT, confirmed through higher gene expression of PPARalpha, PPARbeta, PGC1alpha, BMP8B, UCP-1, PRDM16 and irisin in treated groups. PPARalpha activation seems to be pivotal to trigger browning through irisin induction and UCP-1 transcription, indicating that fenofibrate increased the expression of genes typical of brown adipose tissue (BAT) in the sWAT, characterizing the formation of beige cells. These findings put forward a possible role of PPARalpha as a promising therapeutic for metabolic diseases via beige cell induction.